熊柳冰.白蛋白在预测晚期非小细胞肺癌化疗疗效及预后的价值[J].转化医学杂志,2017,6(6):358-360
白蛋白在预测晚期非小细胞肺癌化疗疗效及预后的价值
Analysis on the fracture of rabbits induced by multiple cabins explosion
  
DOI:
中文关键词:  非小细胞肺癌  白蛋白  化疗  预后
英文关键词:Non small cell lung cancer (NSCLC)  Albumin (ALB)  Chemotherapy  Prognosis
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作者单位
熊柳冰 广东医科大学附属惠东医院肿瘤科 
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中文摘要:
      目的探讨晚期非小细胞肺癌(nonsmall cell lung cancer,NSCLC)患者化疗前、后白蛋白(albumin,ALB)水平对NSCLC化疗疗效及生存预后的影响。方法回顾性分析2003年5月—2010年11月广东医科大学附属惠东医院收治的184例不可手术切除的晚期NSCLC患者的病例资料。按ALB水平将患者分为<35 g/L组和≥35 g/L组,分析患者疾病控制率、生存率。结果无论是化疗前还是化疗后,ALB<35 g/L组与ALB≥35 g/L组的疾病控制率差异均有统计学意义(P<0.05),COX多因素分析均显示体能状况评分及化疗前ALB、化疗后ALB水平差异均有统计学意义(P<0.05)。结论无论化疗前、后,ALB水平均能够预测晚期NSCLC化疗疗效及预后。
英文摘要:
      ObjectiveTo investigate albumin in lung cancer patients before and after chemotherapy and to study the effect of albumin (ALB) on the results of chemotherapy and prognosis of the advanced nonsmall cell cancer (NSCLC). MethodsThe clinical data of 184 patients with unresectable NSCLC who were admitted in the Affiliated Huidong Hospital of Guangdong Medical University from May 2003 to November 2010 were retrospectively analyzed. The patients were divided into ALB<35 g/L group and ALB≥35 g/L group before and after treatment. The disease control rate and survival rate of the patients were analyzed. ResultsWhether before or after chemotherapy,the difference on disease control rate between ALB<35 g/L group and ALB≥35 g/L group were statistically significant (P<005). COX regression shown that performance status score, albumin before chemotherapy and albumin after chemotherapy with advanced NSCLC were statistically significant (P<005) . ConclusionWhether before or after chemotherapy, albumin can predict chemotherapy efficacy and prognosis in advanced NSCLC.
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