张自强,丁芳,张以河,安琪,徐荣荣,刘明东.喜勒可吸收生物修复膜治疗下颌角区骨缺损实验研究[J].转化医学杂志,2018,7(3):146-149
喜勒可吸收生物修复膜治疗下颌角区骨缺损实验研究
Experimental study of induced mandibular defects treated by Healer bioresorbable collagen membrane
  
DOI:
中文关键词:  引导骨再生  骨缺损  可吸收生物修复膜
英文关键词:Guided bone regeneration  Bone defect  Bioresorbable collagen membrane
基金项目:北京市科技计划专项课题(Z1601010427)
作者单位
张自强 北京非金属矿物与固废资源材料化利用北京市重点实验室中国地质大学材料科学与工程学院北京湃生生物科技有限公司 
丁芳 首都医科大学附属北京安贞医院口腔科 
张以河 北京非金属矿物与固废资源材料化利用北京市重点实验室中国地质大学材料科学与工程学院 
安琪 北京非金属矿物与固废资源材料化利用北京市重点实验室中国地质大学材料科学与工程学院 
徐荣荣 北京湃生生物科技有限公司 
刘明东 北京湃生生物科技有限公司 
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中文摘要:
      目的 本研究旨在对比喜勒可吸收生物修复膜与市售生物修复膜修复骨缺损的效果。方法 12只兔子分为2组:喜勒可吸收生物修复膜组6只(左侧植入自体骨覆盖喜勒可吸收生物膜,右侧不植骨不覆膜),市售生物膜组6只(左侧不植骨不覆膜,右侧植入自体骨覆盖市售生物膜),在生理盐水充分冷却的条件下,采用直径为6 mm的球钻在兔下颌骨左右两侧下颌角区分别制备直径6 mm洞穿性的骨缺损。覆盖生物膜,需超出缺损边缘2 mm,分层缝合创口。术后3 d每天皮下注射抗生素。分别于术后1个月、3个月采用空气栓塞法处死实验兔,取整个下颌骨。结果 X线及组织学检查结果显示,术后1个月覆膜的动物骨缺损有不同程度修复,而不覆盖膜的骨缺损均明显存在,且骨缺损内有肌肉长入,但喜勒可吸收生物修复膜组具有完整的生物膜结构。术后3个月覆膜的骨缺损区均有新骨形成,而不覆膜缺损区被结缔组织填充,没有新骨形成。结论 喜勒可吸收生物膜与市售生物修复膜均能有效阻挡软组织长入骨缺损区,作为骨细胞载体促进骨修复,但喜勒可吸收生物修复膜有较强的抗降解能力。
英文摘要:
      Objective To compare the effect of Healer bioresorbable collagen membrane and bio-membrane from the market for bone defect in rabbits. Methods A 6 mm in diameter bone defect was induced in bilateral mandible angle of 12 New Zealand rabbits, those 12 rabbits were divided into two groups. The defect of mandible angle of 6 New Zealand rabbits were covered laterally and medially by Healer bioresorbable collagen membrane (left side) and the right side as blank control don’t cover anything. The defect of mandible angle of 6 New Zealand rabbits were covered by bio-membrane from the market (right side), the left side as blank control don’t cover anything. Six rabbits were sacrificed in the first months, and the others were sacrificed in the third month. ResultsThe X-ray and histological examination showed that in the first month the bone defect was come to repaired and the Healer group had complete biomembrane structure, the bone defect was still evident in the blank control group; in the third month all the membrane-covered partly defects healed with new formed bone, while no new bone was formed in control group, but the defects were filled with soft tissue. Conclusion Healer bioresorbable collagen membrane and bio-membrane from the market can effectively block off soft tissue and serve as osteocyte scaffold to promote the healing of the bone defects. The Healer bioresorbable collagen membrane has stronger anti-degradation ability.
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